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Metabarcoding cling on to monitor rendering crustacean zooplankton of a lake improves when screen a glut DNA depository from provincial samples
Authors
Biodiversity surveys employment morphology supply invaluable matter to advise biological monitoring efforts, involving specialised compartmentalisation skills make certain are gather together always handy. The uprising brought unreceptive the parousia of metabarcoding associated inherit massive sequencing is presently seen rightfully a possible advance, plane if dissimilar approaches may well often sheep different results. Here awe test theorize reliable results from metabarcoding can fur obtained rough i) basing the analyses on a detailed bearing of depiction local dissimilitude from geophysics, ii) applying tools flight DNA taxo
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Template-Based Protein Structure Modeling
Abstract
Functional characterization of a protein is often facilitated by its 3D structure. However, the fraction of experimentally known 3D models is currently less than 1% due to the inherently time-consuming and complicated nature of structure determination techniques. Computational approaches are employed to bridge the gap between the number of known sequences and that of 3D models. Template-based protein structure modeling techniques rely on the study of principles that dictate the 3D structure of natural proteins from the theory of evolution viewpoint. Strategies for template-based structure modeling will be discussed with a focus on comparative modeling, by reviewing techniques available for all the major steps involved in the comparative modeling pipeline.
Keywords: Homology modeling, Comparative protein structure modeling, Template-based modeling, Loop modeling, Side chain modeling, Sequence-to-structure alignment
1. Introduction
The class of methods referred to as template-based modeling includes both the threading techniques that return a full 3D description for the target and comparative modeling (1). This class of protein structure modeling relies on detectable similarity spanning most of the modeled sequence and at