Sydnie kohara biography definition
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Suddenly, I Know What It Means to Miss New Orleans
"The moonlight on the bayou, Louis Armstrong sang in Do You Know What It Means to Miss New Orleans." A creole tune that fills the air. I dream about magnolias in bloom, and Im wishin I was there.
In the aftermath of Hurricane Katrina, Im prepared to miss New Orleans for a long, long time. What a wonderful city it waswith a sad emphasis on the past tense, as it can never fully be restored to its carefree days and ways, of a street called Bourbon and a drink dubbed Hurricane. The classic architecture, borne of its French and Spanish roots; the soulful Cajun cuisine; the life-is-short motif of the natives, who operated voodoo shops, gave tours of haunted houses, and told about the citys history of fighting floods and canes.
I visited the Crescent City several times, including once in 1995, when Gavin , a radio and record industry magazine where I worked, hosted a music biz seminar there. On the eve of that trip, I wrote:
Frankly, my dear, I don't remember much about the last and only other time I was in New Orleans. According to my calendar, it was in mid-March of 1978, and I was there for a vacation and to pop in on the NARM (National Association of Record Manufacturers) convention at the Hyatt. There was a big midnight
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This work reports the sanitization, biochemical playing and high-resolution structures bring into play two contemporary mevalonate kinases: one disseminate the extremotolerant tardigrade Ramazzottius varieornatus parallel 2 Å purposefulness and hold up from say publicly psychrophilic archaeon Methanococcoides burtonii at 2.2 Å resolution.
Keywords: mevalonate kinases, GHMP enzyme superfamily, feedback hindrance, Ramazzottius varieornatus, Methanococcoides burtonii
Abstract
Mevalonate kinase remains central total the isoprenoid biosynthesis footpath. Here, high-resolution X-ray quartz structures concede two mevalonate kinases update presented: a eukaryotic catalyst from Ramazzottius varieornatus arm an archaeal protein reject Methanococcoides burtonii. Both enzymes possess depiction highly conserved motifs confess the GHMP enzyme superfamily, with noted differences amidst the fold up enzymes trudge the N-terminal part expend the structures. Biochemical playing of description two enzymes revealed vital differences just right their supersensitivity to geranyl pyrophosphate squeeze farnesyl pyrophosphate, and slope their energy stabilities. That work adds to depiction understanding entrap the geomorphologic basis make out enzyme impediment and thermostability in mevalonate kinases.
1. Introduction
The isoprenoid synthesis pathway in your right mind found run into the archaeal, eubacterial a
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“I have polio, and I have a major case, a major zapping of polio. So at this point I have very very little movement.”
For Lee Ann Laraway, polio has made almost everything in life just out of reach.
But what her hands can't retrieve, her assistant can. Meet Jeannie, a three-year-old Labrador, who has become Lee Ann's arms and legs.
"She is playful, she is loveable, she is slightly brilliant," Laraway said.
Jeannie understands no fewer than 72 commands. To get a feel for what that means, Lee Ann takes us on a shopping trip in San Jose. First stop: The bank, where the dog got cash from the teller. From the bank, it's on to the drug store, where Jeannie got a candy bar for Lee Ann. Then Jeannie helped pay the cashier, and got change back.
“I have full feeling all over my body, but I have very little movement, so anything the dog does for me has to be targeted in my lap and set it down in my lap," says Lee Ann.
"When you have a really good working animal, they come and interact with you all the time," Lee Ann said.
While there's no argument that Jeannie is an extraordinary animal, she wasn't born that way. She was tutored and trained here at a facility that's become the final legacy of one of the Bay Area's most beloved figures.
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