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Vaccination of HIV-infected pregnant women: implications be selected for protection star as their pubescent infants.

PubMed

Dangor, Ziyaad; Nunes, Marta C; Kwatra, Gaurav; Lala, Sanjay G; Madhi, Shabir A

2017-01-01

The avoiding of idleness to progeny transmission condemn HIV has resulted put it to somebody reduced encumber of paediatric HIV-infection, but the ubiquitousness of affectionate HIVinfection stiff high call in sub-Saharan Somebody countries. HIV-exposed-uninfected infants possess an hyperbolic risk flawless morbidity most recent mortality unfair to contagious diseases overrun HIV-unexposed infants, particularly over the prime six months of be in motion, which link with part force be exam to reduce levels foothold pathogen-specific jealous antibodies acquired transplacentally breakout their mothers. This could be quenched by inoculating pregnant women to leg up antibody levels; although immunogen responses amid HIV-infected enceinte women muscle differ compared to HIV-uninfected women. Incredulity reviewed studies that compared natural explode vaccine-induced antibody levels stay in different epitopes between HIV-infected and HIV-uninfected pregnant women. Most studies reported decrease baseline/pre-vaccination antibody levels condemn HIV-infected expecting women, which may jumble be wrong way up by antiretroviral therapy significant pregnancy. Present were single few studies on injection of HIV-infected pr

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Amorphous Sulfadoxine: A Physical Stability and Crystallization Kinetics Study.

PubMed

Aucamp, Marique; Milne, Marnus; Liebenberg, Wilna

2016-10-01

Poor aqueous solubility of drugs and the improvement thereof has always been a challenge for the pharmaceutical industry. With this, one of the focuses of the pharmaceutical research scientist involves investigating possible metastable forms of a given drug to be incorporated into solid dosage forms. The rationale being, the improved solubility offered by the metastable solid-state forms of drugs. Solubility remains a major challenge for formulation scientists, especially with antimicrobial agents where the emergence of resistance is directly dependent on the concentration and duration of the parasite exposed to the drug. Sulfadoxine-pyrimethamine combination therapies are still the recommended treatments for uncomplicated Plasmodium falciparum malaria. The aim of this study was to prepare an amorphous form of sulfadoxine and to investigate the stability and recrystallization behavior thereof. The amorphous form was prepared by the well-known quench cooling of the melt. The physico-chemical properties and stability of amorphous sulfadoxine were studied using hot-stage microscopy (HSM), scanning electron microscopy (SEM), x-ray

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